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“Our purpose is to grasp woman reproductive getting old, and why fertility quickly declines starting inside the mid-30s,” suggests Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata performs.

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This enables the oocytes to pause their development and enter a holding sample, which lasts in the mouse’s adulthood. In mice missing PRC1, the oocytes didn’t pause their advancement; rather, they withered and died inside of a thirty day period, leaving the mice permanently infertile.

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Each one consists of a mass of thread-like DNA — akin to four hundred miles of yarn. To keep it from devolving into a tangle, the DNA is wrapped all around a number of protein spools, referred to as nucleosomes.

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This protein could “create and manage the chromatin state,” states Namekawa — trying to keep the spools set up and the oocytes genetically primed because the mouse matures.

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